Showing posts with label healthcare. Show all posts

Saturday 4 October 2014

Medical first: Baby born to woman who got new womb

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(AP) — In a medical first, a woman in Sweden has given birth after receiving a womb transplant, the doctor who performed the pioneering procedure said Friday.
The 36-year-old mother received a uterus from a close family friend last year. Her baby boy was born prematurely but healthy last month, and mother and child are now at home and doing well. The identities of the woman and her husband were not disclosed.
"The baby is fantastic," said Dr. Mats Brannstrom, a professor of obstetrics and gynecology at the University of Gothenburg and Stockholm IVF who led the research and delivered the baby with the help of his wife, a midwife. "But it is even better to see the joy in the parents and how happy he made them."
Brannstrom said it was "still sinking in that we have actually done it."
The feat opens up a new but still experimental alternative for some of the thousands of women each year who are unable to have children because they lost a uterus to cancer or were born without one. Before this case proved the concept can work, some experts had questioned whether a transplanted womb would be able to nourish a fetus.
Others have questioned whether such an extreme step — expensive and fraught with medical risks — would even be a realistic option for many women.
Dr. Glenn Schattman, past president of the Society for Assisted Reproductive Technologies and a Cornell University fertility specialist, said womb transplants are likely to remain very uncommon.
"This would not be done unless there were no other options," he said. "It requires a very long surgery and not without risk and complications."
For the proud parents, the years of research and experimentation were well worth the wait.
"It was a pretty tough journey over the years, but we now have the most amazing baby," the father said in a telephone interview. "He is very, very cute, and he doesn't even scream, he just murmurs."
He said he and his wife, both competitive athletes, were convinced the procedure would work, despite its experimental nature.
Brannstrom and colleagues transplanted wombs into nine women over the last two years as part of a study, but complications forced removal of two of the organs. Earlier this year, Brannstrom began transferring embryos into the seven other women. He said there are two other pregnancies at least 25 weeks along.
Before these cases, there had been two attempts to transplant a womb — in Saudi Arabia and Turkey — but no live births resulted. Doctors in Britain, France, Japan, Turkey and elsewhere are planning to try similar operations, but using wombs from women who have just died instead of from live donors.
The Swedish woman had healthy ovaries, but she was born without a uterus — a syndrome seen in one girl in 4,500. She received a uterus from a 61-year-old family friend who had gone through menopause after giving birth to two children.
Brannstrom said that he was surprised such an old uterus was so successful, but that the most important factor seemed to be that the womb was healthy.
The recipient has had to take three medicines to prevent her body from rejecting the new organ. About six weeks after the transplant, she got her menstrual period — a sign the womb was healthy.
After one year, when doctors were confident the womb was working well, they transferred a single embryo created in a lab dish using the woman's eggs and her husband's sperm.
The woman, who has only one kidney, had three mild rejection episodes, including one during pregnancy, but all were successfully treated with medicines. The research was paid for by the Jane and Dan Olsson Foundation for Science, a Swedish charity.
The baby's growth and blood flow to the womb and umbilical cord were normal until the 31st week of pregnancy, when the mother developed a dangerous high-blood-pressure condition called preeclampsia.
After an abnormal fetal heart rate was detected, the baby was delivered by cesarean section. He weighed 3.9 pounds — normal for that stage of pregnancy. Full gestation is about 40 weeks. The baby was released from the neonatal unit 10 days after birth.
"He's no different from any other child, but he will have a good story to tell," the father said. "One day he can look at the newspaper articles about how he was born and know that he was the first in the world" to be born this way.
Details of the case are to be published soon in the journal Lancet.
Some critics have said that taking a womb from a live person is unethical and too big a risk to the donor for an operation that isn't life-saving. But Brannstrom said there were too few deceased donors to consider that option in Sweden.
"Most couples will do just about anything to have a baby. We need to see this happen a little bit more and see how safe it is," said Dr. Nanette Santoro, obstetrics chief at the University of Colorado in Denver. "It's not clear to me how many women would choose this, because it seems pretty arduous."
Brannstrom said he was concerned he might have hurt the womb during the C-section and said they would have to wait a couple of months before knowing if the mother would be able to keep the uterus for a second pregnancy.
For the new parents, the thought of a second baby right now is a little premature.
"We will definitely think about that," the father said. "But right now, we're very happy with just one baby."

Friday 3 October 2014

Facebook plots first steps into healthcare

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(Reuters) - Facebook Inc (FB.O) already knows who your friends are and the kind of things that grab your attention. Soon, it could also know the state of your health.

On the heels of fellow Silicon Valley technology companies Apple Inc (AAPL.O) and Google Inc (GOOGL.O), Facebook is plotting its first steps into the fertile field of healthcare, said three people familiar with the matter. The people requested anonymity as the plans are still in development.

The company is exploring creating online "support communities" that would connect Facebook users suffering from various ailments. A small team is also considering new "preventative care" applications that would help people improve their lifestyles.

In recent months, the sources said, the social networking giant has been holding meetings with medical industry experts and entrepreneurs, and is setting up a research and development unit to test new health apps. Facebook is still in the idea-gathering stage, the people said.

Healthcare has historically been an area of interest for Facebook, but it has taken a backseat to more pressing products.

Recently, Facebook executives have come to realize that healthcare might work as a tool to increase engagement with the site.

One catalyst: the unexpected success of Facebook's "organ-donor status initiative," introduced in 2012. The day that Facebook altered profile pages to allow members to specify their organ donor-status, 13,054 people registered to be organ donors online in the United States, a 21 fold increase over the daily average of 616 registrations, according to a June 2013 study published in the American Journal of Transplantation.

Separately, Facebook product teams noticed that people with chronic ailments such as diabetes would search the social networking site for advice, said one former Facebook insider. In addition, the proliferation of patient networks such as PatientsLikeMe demonstrate that people are increasingly comfortable sharing symptoms and treatment experiences online.

Chief executive Mark Zuckerberg may step up his personal involvement in health. Zuckerberg and his wife Priscilla Chan, a pediatric resident at University of California San Francisco, recently donated $5 million to the Ravenswood Health Center in East Palo Alto.

Any advertising built around the health initiatives would not be as targeted as it could be on television or other media. Pharmaceutical companies, for instance, are prohibited from using Facebook to promote the sale of prescription drugs, in part because of concerns surrounding disclosures.

PRIVACY CONCERNS

Privacy, an area where the company has faced considerable criticism over the years, will likely prove a challenge. This week, the company apologized to users for manipulating news feeds for the purposes of research.

But Facebook may already have a few ideas to alleviate privacy concerns around its health initiatives. The company is considering rolling out its first health application quietly and under a different name, a source said. Market research commissioned by Facebook found that many of its users were unaware that photo-service Instagram is Facebook-owned, the source said.

Facebook's recent softening of its policy requiring users to go by their real names may also bolster the company's health plans. People with chronic conditions may prefer to use an alias when sharing their health experiences.

"I could see Facebook doing well with applications for lifestyle and wellness, but really sick patients with conditions like cancer aren't fooling around," said Frank Williams, chief executive of Evolent Health, a company that provides software and services to doctors and health systems.

People would need anonymity and an assurance that their data and comments wouldn't be shared with their online contacts, advertisers, or pharmaceutical companies, Williams said.

It remains unclear whether Facebook will moderate or curate the content shared in the support communities, or bring in outside medical experts to provide context.

Facebook declined to comment on its health care plans.

Thursday 2 October 2014

Many sick in US Ebola patient's Liberia hometown

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(AP) — Thomas Eric Duncan rushed to help his 19-year-old neighbor when she began convulsing days after complaining of stomach pain. Everyone assumed her illness was related to her being seven months pregnant.

When no ambulance came, Duncan, Marthalene Williams' parents and several others lifted her into a taxi, and Duncan rode in the front seat as the cab took Williams to the hospital. She later died.

Within weeks, everyone who helped Williams that day was either sick or dead, too — victims of Ebola, the virus that is ravaging Liberia's capital and other parts of West Africa, with more than 3,300 deaths reported.

The disease is spread through direct contact with saliva, sweat, blood and other bodily fluids, and all those who fell ill after helping Williams had touched her. She turned out to have Ebola.

Duncan is now hospitalized in an isolation ward in Texas after falling sick with Ebola following his arrival last month on a family visit. He has become a symbol of how the lethal disease could spread within the U.S.

Here in Liberia, however, he is just another neighbor infected by a virus that is devastating the cluster of tin-roof homes along 72nd SKD Boulevard where Williams lived.

"My pa and four other people took her to the car. Duncan was in the front seat with the driver, and the others were in the back seat with her," recounted her 15-year-old cousin Angela Garway, standing in the courtyard between the homes where they all lived. "He was a good person."

Meanwhile, Liberian authorities Thursday announced plans to prosecute Duncan, saying the delivery driver lied about his Ebola status upon leaving the country.

On an airport screening questionnaire obtained by The Associated Press, Duncan said that he hadn't come into contact with an Ebola patient. However, it is not clear whether he had learned of Williams' diagnosis before traveling.

In the neighborhood where Williams lived, some people were no longer willing to take any risks Thursday, not after seeing what happened to those who showed compassion for the pregnant woman.

As 9-year-old Mercy Kennedy sobbed along with neighbors mourning news of her mother's death, not a person would touch the little girl to comfort her.

Mercy's mother had helped to wash the pregnant woman's clothes, and had touched her body after she died at home when no hospital could find space for her, neighbors said.

On Thursday, little Mercy walked around in a daze in a torn nightgown and flip-flops, pulling up the fabric to wipe her tears as a group of workers from the neighborhood task force followed the sound of wailing through the thick grove of banana trees and corn plants.

"We love you so dearly, yeah," one man wearing rubber gloves told her from a safe distance. "We want to take care of you. Have you been playing with your friends here?"

With Mercy's mother dead, neighbors fear it is only a matter of time before she, too, shows signs of the virus, and they want to know which other children may have come into contact with her while she was fetching water.

Pewu Wolobah, a member of the neighborhood anti-Ebola task force, lamented that even as Americans try to trace all of Duncan's contacts there, the virus is spreading through Duncan's old neighborhood faster than anyone can keep track.

The aunt of the pregnant victim died on Wednesday after collapsing in her house next door to the Williams home. Her 15-year-old daughter Angela is left behind, along with the pregnant woman's three younger siblings — Ezo Williams, 16, Tete Williams, 12, and Stanley Williams, 3 — and the family dog.

Their parents left Thursday morning for an Ebola treatment center. As word spread that they, too, took a taxi, the health workers expressed alarm.

"Does anybody know the taxi number or the license plate?" one man called into the crowd. "We need to find this vehicle!"

All the cases, including Duncan's, appear to have started with Williams, though some wondered how a pregnant woman who stayed at home could have contracted Ebola. Maybe it was her boyfriend, who hasn't been seen in weeks, they said. Or could it have been her close friend known as Baby D, who has since died herself?

The tragedy of Williams' death could grow larger still: Neighbors and relatives said more than 100 people came to a wake for her. No one could say for sure how many people may have touched the body.

"We had a lot of people come from a great distance to sympathize with her family," said Joseph Dolo from the anti-Ebola task force. "She had a lot of friends."

U.S. nears solution for safe disposal of Ebola waste

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(Reuters) - The United States is days away from settling the critical question of how hospitals should handle and dispose of medical waste from Ebola patients, a government official said on Wednesday.

Experts have warned that conflicting U.S. regulations over how such waste should be transported could make it very difficult for U.S. hospitals to safely care for patients with Ebola, a messy disease that causes diarrhea, vomiting and in some cases, bleeding from the eyes and ears.

Safely handling such waste presents a dual challenge for regulators, who want to both prevent the accidental spread of the deadly disease and avert any deliberate attempts to use it as a bioweapon.

Most U.S. hospitals are not equipped with incinerators or large sterilizers called autoclaves that could accommodate the large amounts of soiled linens, contaminated syringes and virus-spattered protective gear generated from the care of an Ebola patient, said Dr. Jeffrey Duchin, chair of the Infectious Diseases Society of America's Public Health Committee.

Sterilizing Ebola waste before it is transported is important not only to protect waste haulers but to guard against someone using the waste "for nefarious purposes," said Sean Kaufman, ‎president of Behavioral-Based Improvement Solutions, an Atlanta-based biosafety firm. "It's not just a safety issue," he said.

The matter, which was first reported by Reuters last month, may pose a significant challenge for Texas Health Presbyterian Hospital in Dallas, which is now treating the first Ebola patient to be diagnosed on U.S. soil.

Duchin said he is not aware of whether the hospital has its own incinerator or large autoclave, but if it does not, "they are going to have to find a temporary solution for managing infectious waste. That puts the hospital in a very difficult situation."

Cynthia Quarterman, administrator of the U.S. Department of Transportation's Pipeline and Hazardous Material Safety Administration, which oversees dangerous shipments, said her agency is "working on how we can clarify even further for hospitals, for the public, what the appropriate transportation should be."

Another official said that news could come within days.

The issue centers on guidance over handling Ebola-contaminated waste. The U.S. Centers for Disease Control and Prevention advises hospitals to treat items infected with the Ebola virus in leak-proof containers and discard them as they would other biohazards that fall into the category of "regulated medical waste."

But the DOT deems Ebola a Category A infectious agent, meaning it is capable of killing people and animals, and not "regulated medical waste," a category in which pathogens are not capable of causing harm.

Waste management contractors who normally handle hazardous hospital waste say they cannot legally haul the material, which leaves hospitals stuck without a way to dispose of the waste.

Already the issue has created problems. When Emory University Hospital in Atlanta was preparing to care for two U.S. missionaries infected with Ebola in West Africa in its high-security biocontainment unit, their waste hauler, Stericycle, initially refused to handle it.

Bags of Ebola waste quickly began piling up until the hospital worked out the issues with the help of the U.S. Centers for Disease Control and Prevention.

CDC spokesman Tom Skinner said the waste management problem has not been resolved yet, but he has said previously that the CDC is meeting with officials at the DOT to resolve the matter.

Duchin said he has heard that the discussion "has been elevated at the fed to decision makers who can solve the problem."

A DOT official said the CDC and DOT will likely issue joint guidance by next week.

Wednesday 1 October 2014

Global spa, wellness industry estimated at $3.4 trillion

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(Reuters) - A growing middle class and consumers' evolving attitudes toward health and travel have fueled a global spa and wellness industry worth an estimated $3.4 trillion in 2013, according to a report released on Tuesday.

Nutrition and weight loss, preventative and personalized health, complementary and alternative medicine, and beauty and anti-aging treatments were the biggest growing sectors, the report compiled by the non-profit research center SRI International showed.

"All across the world we have seen, from Asia to Europe to Africa to North America, more and more people are consciously thinking about healthy food, exercising, looking to nature, getting massages and doing yoga," said Ophelia Yeung, a senior consultant for SRI International who led the study.

Spa treatments and products, alternative and complementary treatments and weight-loss programs once considered beyond the means of many people, she added, are becoming more mainstream with a growing middle class.

While medical care treats illness and disease, wellness is focused on prevention through a variety of healthy habits, nutritional eating, exercise and treatments.

To compile the report researchers looked at wellness sectors ranging from mind and body fitness to beauty and anti-aging, spas and workplace wellness.

The global spa industry generated $94 billion last year, according to the Global Spa and Wellness Economy Monitor report, up from $60 billion in 2007.

With more than 32,000 spas, Europe had the highest revenue of $29.8 billion, followed by the Asia-Pacific region with $18.8 billion and North America with $18.3 billion.

Emerging markets in the Middle East and Africa have been growing the fastest in terms of adding spas. In Asia, China and India are leading growth, while in Europe it is Eastern Europe, Russia and the Baltic states.

Thermal/mineral springs generated $50 billion worldwide but the biggest industry sector was wellness tourism, or travel associated with maintaining or enhancing one's personal well-being and health, which accounted for $494 billion.

"Wellness travel is a very fast growing segment within travel. That's because as people become more conscious about a healthy lifestyle they naturally want to extend that when they travel," Yeung explained.

The report showed that the number of people taking international and domestic wellness tourism trips grew by 12 percent from 2012 to 2013. That was 36 percent faster than overall tourism trip growth, which is estimated at 9 percent.

The SRI report was commissioned by the annual Global Spa & Wellness Summit. More than 400 wellness industry leaders from 45 countries attended the 2014 summit in Morocco earlier this month.

Sunday 28 September 2014

New Mosquito-Borne Virus Spreads In Latin America

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(AP) — An excruciating mosquito-borne illness that arrived less than a year ago in the Americas is raging across the region, leaping from the Caribbean to the Central and South American mainland, and infecting more than 1 million people. Some cases already have emerged in the United States.

While the disease, called chikungunya, usually is not fatal, the epidemic has overwhelmed hospitals, cut economic productivity and caused its sufferers days of pain and misery. And the count of victims is soaring.

In El Salvador, health officials report nearly 30,000 suspected cases, up from 2,300 at the beginning of August, and hospitals are filled with people with the telltale signs of the illness, including joint pain so severe it can be hard to walk.

"The pain is unbelievable," said Catalino Castillo, a 39-year-old seeking treatment at a San Salvador hospital. "It's been 10 days and it won't let up."

Venezuelan officials reported at least 1,700 cases as of Friday, and the number is expected to rise. Neighboring Colombia has around 4,800 cases but the health ministry projects there will be nearly 700,000 by early 2015. Brazil has now recorded its first locally transmitted cases, which are distinct from those involving people who contracted the virus while traveling in an infected area.

Hardest hit has been the Dominican Republic, with half the cases reported in the Americas. According to the Pan American Health Organization, chikungunya has spread to at least two dozen countries and territories across the Western Hemisphere since the first case was registered in French St. Martin in late 2013.

There have been a few locally transmitted cases in the U.S., all in Florida, and it has the potential to spread farther, experts say, but Central and South America are particularly vulnerable. The chief factors are the prevalence of the main vector for the virus, the aedes aegypti mosquito, and the lack of immunity in a population that hasn't been hit with chikungunya in modern medical history, said Scott C. Weaver, director of the Institute for Human Infections and Immunity at the University of Texas Medical Branch.

"There are going to be some very large populations at risk down there, much larger than the Caribbean," Weaver said.

Chikungunya is a word that comes from the Makonde language of Tanzania in eastern Africa and translates roughly as "that which bends up," in reference to the severe arthritis-like ache in joints that causes sufferers to contort with pain. It's usually accompanied by a spiking fever and headache. There have been only 113 deaths linked to the region's outbreak, according to the most recent data, but chikungunya can be crippling.

Herman Slater, a 60-year-old gardener in Jamaica's capital of Kingston, said he was laid out for almost two weeks this month with unimaginable joint pain, hammer-pounding headaches and fevers that came in waves.

"I tell you, I was surprised by how painful it was. It was taking me five minutes to get out of bed, and then I could hardly even walk," Slater said. "My hands were so bad I couldn't open a bottle, couldn't comb my hair. Every night I was wet from sweat."

In acute cases, pain can last for months. Joanna Rivas, who works as a maid in the Dominican capital of Santo Domingo, said she has had joint pain since May, and her 12-year-old daughter's case is so severe the girl can't hold her pen at school. Both have been taking the pain reliever acetaminophen, the main treatment for chikungunya, which has no cure or vaccine.

Besides the suffering, chikungunya has caused economic damage with the cost of providing treatment and controlling mosquitoes and by absenteeism from work. A study by the Universidad Eugenio Maria de Hostos in the Dominican Republic found nearly 13 percent of businesses said they had people miss work because of chikungunya in June.

Authorities throughout the region have been spraying pesticide and encouraging people to remove water containers where mosquitoes can breed. Oxitec, a British company that has tested genetically modified aedys aegypti to combat dengue in Brazil, Cayman Islands and Panama, says it has received a surge of interest since the start of the outbreak.

Chikungunya, which has been known for decades in parts of Africa and Asia, is transmitted when a mosquito bites an infected person and then feeds on someone else. It may have found fertile ground in Latin America and the Caribbean because many people are outside in the daytime, when aedes aegypti bite, or lack adequate screens on their windows.

In an article in the New England Journal of Medicine, Dr. Erin Staples of the U.S. Centers for Disease Control and Prevention said access to air conditioning to keep mosquitoes at bay might also be a factor. During an outbreak of mosquito-borne dengue in 1999 along the Texas-Mexico border, aedes aegypti were three times as abundant on the U.S. side but the number of people infected with dengue was twice as high on the Mexican side.

Conditions vary widely in the region. Haiti, where many people live in flimsy shacks with little protection from mosquitoes, has been hit hard. In Venezuela, air conditioning is widespread but the country has a shortage of insect repellent and pesticide sprayers due to the country's economic problems.

Staples said past outbreaks have been known to affect around 30 percent of a population, so there is room for the epidemic to grow, although it's too early to accurately project how many will get sick or whether chikungunya will become endemic to the region like dengue.

The good news is that people seem to acquire immunity to all major strains.

"We do believe currently that if someone is unfortunate enough to get infected, they should not be infected again," Staples said.

Saturday 27 September 2014

Early data promising for AstraZeneca cancer drug combination

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(Reuters) - Early results for a closely watched cancer drug combination from AstraZeneca that boosts the immune system show the cocktail is promising, though limited patient numbers mean the data is far from conclusive.

The British drugmaker, which fended off a $118 billion takeover bid from Pfizer in May in part by talking up its cancer drug prospects, has high hopes for the combination of two experimental drugs known as MEDI4736 and tremelimumab.

The company is still exploring a range of doses, so testing of the drugs in lung cancer is taking time to yield results and data on only two dozen patients was reported at the European Society for Medical Oncology (ESMO) congress on Saturday.

Chief Executive Pascal Soriot had said earlier this month that the ESMO numbers would be limited.

Still, researcher Scott Antonia of the Moffitt Cancer Center in Florida said the early signals were encouraging, both for safety and efficacy. "It looks very, very promising," he said.

AstraZeneca expects to have more definitive results later this year and also plans to start a pivotal clinical trial with the combination either late this year or at the start of 2015.

Immunotherapy treatment is the hottest area of cancer research - widely tipped to become a market worth tens of billions of dollars in annual sales - and combinations are viewed by many oncologists as the best way to use the new drugs.

Safety, however, is an issue, especially after results from another small study with a similar Bristol-Myers Squibb cocktail showed about half of patients experienced serious side effects, with three treatment-related deaths.

In the case of AstraZeneca's combination, six out of 24 advanced lung cancer patients had adverse events rated as serious, or grade 3/4, and three had events that led to discontinuation of treatment. There was one treatment-related death.

So far, 18 of the patients have been assessed for efficacy and five of these, or 28 percent, had tumor shrinkage, according to research presented at the meeting in Madrid.

Although direct comparisons are difficult, Antonia said this was much better than the efficacy benefit seen with the Bristol-Myers combination in lung cancer.

"In terms of what you would hope to see at this point, we are very much on track," Edward Bradley, head of oncology at AstraZeneca's biotech unit MedImmune, told Reuters. "It's early days but we're pleased with where we are and I think it's a very manageable tolerability profile."

$6.5 BILLION FORECAST

AstraZeneca already presented data on a handful of patients at the American Society of Clinical Oncology earlier this year. The new results build on that by providing more safety data and showing some evidence of clinical activity in sick patients who have failed to respond to other drugs.

MEDI4736 is part of a class of drugs known as anti-PD-L1 therapies, which work by blocking a tumor's ability to evade the immune system's defenses. Tremelimumab is a so-called anti-CTLA4 drug that unlocks a different brake on the immune system.

The two-pronged approach is designed to expose cancer cells as fully as possible to the killing power of the body's own immune system. But boosting the immune system can cause damaging side effects, including colitis, a serious inflammation of the colon, as well as liver and thyroid problems.

Immunotherapy drugs are seen as AstraZeneca's most important pipeline assets and the company has predicted that MEDI4736 could generate annual sales of $6.5 billion, including its use in combinations.

AstraZeneca is vying with rivals Bristol-Myers Squibb, Merck & Co and Roche in the immunotherapy race.

It is viewed by analysts as being behind these leaders but the company has a long history in cancer treatment and believes it is in a good position to develop a wide range of drug cocktails.

Because such immunotherapy does not work for all patients, some companies have looked to focus on people whose tumors test positive for a likely response. However, most of the patients assessed in the AstraZeneca study were actually PD-L1 negative.

"This supports our strategy to explore this combination more broadly, particularly in the PD-L1 negative population," Bradley said.

Currently, immunotherapy is most advanced as a treatment for melanoma but research is advancing rapidly into other tumor types, with non-small cell lung cancer - a major killer - the biggest commercial opportunity.

As a result, doctors and investors alike are following the AstraZeneca drug combination very closely, particularly after the earlier disappointment with Bristol-Myers' combination using nivolumab and its already approved drug Yervoy.

Friday 26 September 2014

Money talks: Obamacare initiative makes headway in Republican states

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(Reuters) - President Barack Obama’s plan to extend health coverage to millions of poor Americans remains highly contentious, yet it is gaining momentum among several initially reluctant states where financial pragmatism is trumping ideology.

Up to a dozen states, including several led by Republicans, could move forward with plans to expand coverage under Medicaid after the November elections. They take their cue from Pennsylvania and other states that have won Washington's approval to add commercial innovations to the 50-year-old government program to make it more palatable to conservatives.

Obama's original idea of using tax money to expand Medicaid has long been a hot button for Republicans who portray the whole Obamacare healthcare overhaul as a form of socialism encroaching on American values of free enterprise and self-reliance. Texas Governor Rick Perry once said expanding Medicaid would be similar to "adding a thousand people to the Titanic.”

But two things have led to a change of heart for some Republican politicians.

Most of the 27 states that are already expanding the program have begun to reap billions in federal subsidies for insurers, hospitals and healthcare providers, putting politicians elsewhere under intense pressure to follow suit.

As demonstrated by Pennsylvania's deal with Washington, the Obama administration has also proved willing to accept tweaks that give the private sector a greater role in providing healthcare and place new responsibilities on beneficiaries.

All of that has got as many as nine states talking to the administration about potential expansion terms, with the possibility of up to three more joining the fray depending on November's election outcomes. As a result, there could be even more pressure on Republican states that have opted out, providing critical mass for an initiative central to Obamacare.

Heading into the final two years of his presidency, Obama wants to cement his legacy, a big part of which is his pledge to reduce the number of uninsured Americans.

NEW WAVE

“Pennsylvania’s the leading edge of what could be a new wave of expanding states,” said Deborah Bachrach, a Medicaid expert at the law and consulting firm Manatt, Phelps & Phillips.

“This would marginalize the non-expansion states to the considerable detriment of their citizens and put pressure on those who oppose expansion,” she said.

Some states with Republican governors, such as Indiana, are negotiating with Washington for agreements that could pass political muster with conservatives back home. Others such as North Carolina, South Dakota and Wyoming are exploring options.

In Florida, Wisconsin and Maine, the outcome of the Nov. 4 election could bring a shift on Medicaid if Democrats win gubernatorial races there.

Administration officials have said they are committed to working with all states to expand the scheme and noted that the number of the uninsured has declined much more in states that have expanded Medicaid coverage.

A possible new wave of expansion comes as prospects for the broad Obamacare reform are also looking up. After a rocky start a year ago, research suggests that more than 10 million people have gained health coverage under the law.

But that momentum could get lost if Republicans win control of the U.S. Senate and begin pressuring Obama to scale back the reform.

Pennsylvania's turbulent journey into the Medicaid fold offers a possible template for others, including the possibility of a political reversal if Republican Governor Tom Corbett loses his reelection bid. In polls, he is well behind Democratic challenger Tom Wolf, who favors expanding Medicaid and keeping its traditional structure intact.

Corbett, who took part in a Supreme Court challenge to the Medicaid expansion, had opposed enlarging a government program without substantial change. A pro-Medicaid coalition of more than 100 groups responded with intense lobbying during the budget approval process in early 2013.

“We had advocacy days, drive-ins, invited lawmakers in to talk about what’s important, encouraged people to talk to their local chambers of commerce and organized educational opportunities,” said Paula Bussard, policy chief at the Hospital & Healthsystem Association of Pennsylvania, which represents 250 institutions.

A study by the RAND Corp predicted a $3 billion economic boost and the creation of 35,000 jobs – big advantages for a state that has struggled for decades to make up for jobs lost from the decline of the coal and steel industries.Corbett met in Washington with former U.S. Health and Human Services Secretary Kathleen Sebelius in April 2013 and a year of intensive talks followed.

Pennsylvania won approval for only a handful of the two dozen innovations it sought, such as permission to offer benefits through private insurers and impose premium charges on beneficiaries who earn more than the federal poverty level.

The program will also include incentives for beneficiaries to practice healthy behavior including screenings and set benefit packages according to commercial standards.

Pennsylvania officials say that while a compromise proved possible, that did not mean convergence in political positions.

“The administration comes from a different philosophical background,” said Jennifer Branstetter, Corbett’s policy chief. “They want to make sure that the program’s there for everybody. And we want to make sure it’s there if you need it."

Other Republican-led states hope the Obama administration will allow even greater flexibility.

“The hope is that they'll be less interested in the purity of their original vision and be more interested in cutting deals to get some of these things done," said Tony Venhuizen, spokesman for South Dakota’s Republican Governor Dennis Daugaard, who has been open to a Medicaid expansion.

In some states, pro-expansion politicians are trying to win conservative support by pushing market-based innovations that over time could trim the cost of traditional Medicaid.

"Eventually, they could meld together," said Nebraska Senator Kathy Campbell, a Republican who has helped lead discussions with Washington.

But while the turning tide on Medicaid bodes well for Obamacare, Republicans refuse to concede any points in the ideological battle around the healthcare model.

Wednesday 24 September 2014

U.S. hospitals unprepared to handle Ebola waste

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(Reuters) - U.S. hospitals may be unprepared to safely dispose of the infectious waste generated by any Ebola virus disease patient to arrive unannounced in the country, potentially putting the wider community at risk, biosafety experts said.

Waste management companies are refusing to haul away the soiled sheets and virus-spattered protective gear associated with treating the disease, citing federal guidelines that require Ebola-related waste to be handled in special packaging by people with hazardous materials training, infectious disease and biosafety experts told Reuters.

Many U.S. hospitals are unaware of the regulatory snafu, which experts say could threaten their ability to treat any person who develops Ebola in the U.S. after coming from an infected region. It can take as long as 21 days to develop Ebola symptoms after exposure.

The issue created problems for Emory University Hospital in Atlanta, the first institution to care for Ebola patients here. As Emory was treating two U.S. missionaries who were evacuated from West Africa in August, their waste hauler, Stericycle, initially refused to handle it. Stericycle declined comment.

Ebola symptoms can include copious amounts of vomiting and diarrhoea, and nurses and doctors at Emory donned full hazmat suits to protect themselves. Bags of waste quickly began to pile up.

"At its peak, we were up to 40 bags a day of medical waste, which took a huge tax on our waste management system," Emory's Dr. Aneesh Mehta told colleagues at a medical meeting earlier this month.

Emory sent staff to Home Depot to buy as many 32-gallon rubber waste containers with lids that they could get their hands on. Emory kept the waste in a special containment area for six days until its Atlanta neighbor, the U.S. Centers for Disease Control and Prevention, helped broker an agreement with Stericycle.

While U.S. hospitals may be prepared clinically to care for a patient with Ebola, Emory's experience shows that logistically they are far from ready, biosafety experts said.

"Our waste management obstacles and the logistics we had to put in place were amazing," Patricia Olinger, director of environmental health and safety at Emory, said in an interview.

       

NOT IF, BUT WHEN

The worst Ebola outbreak on record is now projected to infect as many as 20,000 people in West Africa by November, while U.S. officials have said that number could rise above 550,000 by mid-January without an international intervention to contain its spread. Experts say it is only a matter of time before at least some infected patients are diagnosed in U.S. hospitals, most likely walking into the emergency department seeking treatment.

Already there have been several scares. As of Sept. 8, as many as 10 patients have been tested by U.S. hospitals for suspected Ebola cases, Dr. Barbara Knust, team leader for the CDC's Ebola response, said at a medical meeting this month. All tested negative.

The CDC has issued detailed guidelines on how hospitals can care for such patients, but their recommendations for handling Ebola waste differs from the U.S. Department of Transportation, which regulates the transportation of infectious waste.

CDC advises hospitals to place Ebola-infected items in leak-proof containers and discard them as they would other biohazards that fall into the category of "regulated medical waste." According to DOT guidelines, items in this category can't be in a form that can cause human harm. The DOT classifies Ebola as a Category A agent, or one that is potentially life-threatening.

DOT regulations say transporting Category A items requires special packaging and hazmat training.

CDC spokesman Tom Skinner said the agency isn't aware of any packaging that is approved for handling Ebola waste.

As a result, conventional waste management contractors believe they can't legally haul Ebola waste, said Thomas Metzger, communication director for the National Waste & Recycling Association trade group.

   

A TEMPORARY FIX

Part of Emory's solution was to bring in one of the university's large-capacity sterilizers called an autoclave, which uses pressurized steam to neutralize infectious agents, before handing the waste off to its disposal contractor for incineration.

Few hospitals have the ability to autoclave medical waste from Ebola patients on site.

"For this reason, it would be very difficult for a hospital to agree to care for Ebola cases - this desperately needs a fix," said Dr Jeffrey Duchin, chair of the Infectious Diseases Society of America's Public Health Committee.

Dr. Gavin Macgregor-Skinner, an expert on public health preparedness at Pennsylvania State University, said there's "no way in the world" that U.S. hospitals are ready to treat patients with highly infectious diseases like Ebola.

"Where they come undone every time is the management of their liquid and solid waste," said Macgregor-Skinner, who recently trained healthcare workers in Nigeria on behalf of the Elizabeth R. Griffin Research Foundation.

Skinner said the CDC is working with DOT to resolve the issue. He said the CDC views its disposal guidelines as appropriate, and that they have been proven to prevent infection in the handling of waste from HIV, hepatitis, and tuberculosis patients.

Joe Delcambre, a spokesman for DOT's Pipeline and Hazardous Materials Safety Administration, could not say whether requiring hospitals to first sterilize Ebola waste would resolve the issue for waste haulers. He did confirm that DOT is meeting with CDC.

Metzger said his members are also meeting with officials from the DOT, the CDC and the Environmental Protection Agency to sort out the issue.

Until the matter is resolved, however, "We're bound by those regulations," he said.

Your medical record is worth more to hackers than your credit card

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(Reuters) - Your medical information is worth 10 times more than your credit card number on the black market.

Last month, the FBI warned healthcare providers to guard against cyber attacks after one of the largest U.S. hospital operators, Community Health Systems Inc, said Chinese hackers had broken into its computer network and stolen the personal information of 4.5 million patients.

Security experts say cyber criminals are increasingly targeting the $3 trillion U.S. healthcare industry, which has many companies still reliant on aging computer systems that do not use the latest security features.

"As attackers discover new methods to make money, the healthcare industry is becoming a much riper target because of the ability to sell large batches of personal data for profit," said Dave Kennedy, an expert on healthcare security and CEO of TrustedSEC LLC. "Hospitals have low security, so it's relatively easy for these hackers to get a large amount of personal data for medical fraud."

Interviews with nearly a dozen healthcare executives, cybersecurity investigators and fraud experts provide a detailed account of the underground market for stolen patient data.

The data for sale includes names, birth dates, policy numbers, diagnosis codes and billing information. Fraudsters use this data to create fake IDs to buy medical equipment or drugs that can be resold, or they combine a patient number with a false provider number and file made-up claims with insurers, according to experts who have investigated cyber attacks on healthcare organizations.

Medical identity theft is often not immediately identified by a patient or their provider, giving criminals years to milk such credentials. That makes medical data more valuable than credit cards, which tend to be quickly canceled by banks once fraud is detected.

Stolen health credentials can go for $10 each, about 10 or 20 times the value of a U.S. credit card number, according to Don Jackson, director of threat intelligence at PhishLabs, a cyber crime protection company. He obtained the data by monitoring underground exchanges where hackers sell the information.

 

ATTACKS ON THE RISE

The percentage of healthcare organizations that have reported a criminal cyber attack has risen to 40 percent in 2013 from 20 percent in 2009, according to an annual survey by the Ponemon Institute think tank on data protection policy.

Founder Larry Ponemon, who is privy to details of attacks on healthcare firms that have not been made public, said he has seen an increase this year in both the number of cyber attacks and number of records stolen in those breaches.    

Fueling that increase is a shift to electronic medical records by a majority of U.S. healthcare providers.

Marc Probst, chief information officer of Intermountain Healthcare in Salt Lake City, said his hospital system fends off thousands of attempts to penetrate its network each week. So far it is not aware of a successful attack.

"The only reason to buy that data is so they can fraudulently bill," Probst said.

Healthcare providers and insurers must publicly disclose data breaches affecting more than 500 people, but there are no laws requiring criminal prosecution. As a result, the total cost of cyber attacks on the healthcare system is difficult to pin down. Insurance industry experts say they are one of many expenses ultimately passed onto Americans as part of rising health insurance premiums.

Consumers sometimes discover their credentials have been stolen only after fraudsters use their personal medical ID to impersonate them and obtain health services. When the unpaid bills are sent on to debt collectors, they track down the fraud victims and seek payment.    

Ponemon cited a case last year in which one patient learned that his records at a major hospital chain were compromised after he started receiving bills related to a heart procedure he had not undergone. The man's credentials were also used to buy a mobility scooter and several pieces of medical equipment, racking up tens of thousands of dollars in total fraud.

MEDICARE FRAUD

The government's efforts to combat Medicare fraud have focused on traditional types of scams that involve provider billing and over billing. Fraud involving the Medicare program for seniors and the disabled totaled more than $6 billion in the last two years, according to a database maintained by Medical Identity Fraud Alliance.

"Healthcare providers and hospitals are just some of the easiest networks to break into," said Jeff Horne, vice president at cybersecurity firm Accuvant, which is majority-owned by private equity firm Blackstone Group.

"When I've looked at hospitals, and when I've talked to other people inside of a breach, they are using very old legacy systems - Windows systems that are 10 plus years old that have not seen a patch."

KPMG partner Michael Ebert said security has been an afterthought for many medical providers - whether it is building encryption into software used to create electronic patient records or in setting budgets.

"Are you going to put money into a brand new MRI machine or laser surgery or are you going to put money into a new firewall?" he said.

Obamacare to save U.S. hospitals $5.7 billion in uncompensated care

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(Reuters) - The Obama administration on Wednesday said it expects expanded health coverage under the Affordable Care Act to save U.S. hospitals $5.7 billion this year on the cost of caring for uninsured Americans.

A report by the U.S. Department of Health and Human Services said nearly three-quarters of the savings, $4.2 billion, would occur in states that have opted to expand the Medicaid healthcare program for the poor as part of the law, popularly known as Obamacare.

The data may help hospitals press for Medicaid expansion in the 23 states whose governors have not agreed to it, said Health and Human Services Secretary Sylvia Mathews Burwell.

“We’re now at a phase where we’re actually going to start seeing the benefits” of expansion, Burwell told reporters. “It’s actually showing that this provides benefits to states.”

The report is the latest in a series of administration releases intended to show that President Barack Obama's healthcare reform law is working. Wednesday's announcement came weeks before the November mid-term elections, in which Republicans hope voter dislike for the Affordable Care Act will aid their efforts to win control of the U.S. Senate.

Reducing the cost of "uncompensated care" among hospitals, particularly those with large populations of poor people, is a major goal of Obamacare, which offers federally subsidized private insurance to consumers in addition to expanding Medicaid. Overall, 10.3 million uninsured Americans have gained coverage since the law's enrollment provisions took effect a year ago, according to researchers.

The Medicaid expansion, which extends coverage to nearly everyone living near the federal poverty line, has been seen as the main vehicle for reducing uncompensated care for the poor. But only 27 of the 50 U.S. states have agreed to expand the program so far, leaving millions without coverage in the other states.

Burwell said she continues to talk to governors to try to convince them to expand the program, but she told reporters that the positive experience in states that have already made the change is likely to be a bigger influence.

“I think the more that we are able to attract conservative Republican governors, the more that those who have very strong feelings will perhaps listen,” said Burwell, who worked with Pennsylvania’s Republican Governor Tom Corbett to expand the program in his state in August.

“They all talk to each other,” she said.

Monday 22 September 2014

Study of smoking cancer patients fuels e-cigarette debate

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(Reuters) - The fierce debate over whether e-cigarettes can help people quit smoking took another twist on Monday as a research paper on their use by cancer patients was criticized as flawed.
The study of cancer patients who smoke found that those using e-cigarettes as well as tobacco cigarettes were more nicotine dependent and equally or less likely to have quit than those who didn't use e-cigarettes.
The scientists behind the research, which was published online in Cancer, the journal of the American Cancer Society, said their results raised doubts about whether e-cigarettes had any benefit in helping cancer patients to give up smoking.
But that conclusion was questioned by other tobacco and addiction researchers, who said the selection of patients for the study had given it an inherent bias.
The uptake of e-cigarettes, which use battery-powered cartridges to produce a nicotine-laced vapor for the "smoker" to inhale, has rocketed in the past two years, but there is fierce debate about their potential risks and benefits.
Because they are new, there is a lack of long-term scientific evidence on their safety. Some experts fear they could lead to nicotine addiction and be a gateway to tobacco smoking, while others say they have enormous potential to help millions of smokers around the world to quit.
What few studies there are give a mixed picture, with some concluding that e-cigarettes can help people give up a deadly tobacco habit, while others suggest they may carry health risks of their own.
A World Health Organization (WHO) report last month called for stiff regulation of e-cigarettes as well as bans on indoor use, advertising and sales to minors.
But that report itself was also criticized by experts who said it contained errors, misinterpretations and misrepresentations.
For the Cancer journal study, researchers led by Jamie Ostroff of the Memorial Sloan Kettering Cancer Center in New York City studied 1,074 cancer patients who smoked and who were enrolled between 2012 and 2013 in a tobacco treatment program at a cancer center.
They found a three-fold increase in e-cigarette use from 2012 to 2013 - rising from 10.6 percent to 38.5 percent.
At enrolment onto the program, the researchers' analysis found, the e-cigarette users were more nicotine dependent than non-users, had more prior quit attempts, and were more likely to be diagnosed with lung or head and neck cancers.
By the end of the study period, the researchers said, e-cigarette users were just as likely as non-users of e-cigarettes to be smoking.
But Robert West, director of tobacco research at University College London, said the study was not able to assess whether or not for cancer patients who smoke using an e-cigarette to try and quit is beneficial "because the sample could consist of e-cigarette users who had already failed in a quit attempt, so all those who would have succeeded already would be ruled out".  
Peter Hajek, director of the Tobacco Dependence Research Unit at Queen Mary, University of London, agreed that the study's data did not justify the conclusions.
"The authors followed up smokers who tried e-cigarettes but did not stop smoking, and excluded smokers who tried e-cigarettes and stopped smoking," he said.
"Like smokers who fail with any method, these were highly dependent smokers who found quitting difficult. The authors concluded that e-cigarette (use) was not helpful, but that would be true for any treatment however effective if only treatment failures were evaluated."

WHO experts advise against travel or trade bans on Ebola-hit Africa

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(Reuters) - Independent health advisers to the World Health Organization (WHO) have assessed that there should be no general ban on travel or trade with countries reeling from an Ebola epidemic in West Africa, the U.N. agency said on Monday.

Some airlines have stopped flights to affected areas and WHO and other agencies have said this has hampered aid efforts and the ability of experts to reach victims of the world's worst ever outbreak of the hemorrhagic fever.

In a statement issued after the Emergency Committee held its second meeting last week, the WHO said Ebola had now killed at least 2,793 people in five countries and remains a "public health emergency of international concern".

"Flight cancellations and other travel restrictions continue to isolate affected countries, resulting in detrimental economic consequences, and hinder relief and response efforts risking further international spread," the statement said.

"The Committee strongly reiterated that there should be no general ban on international travel or trade..."

The experts urged authorities in the affected countries - Guinea, Liberia, Nigeria, Senegal and Sierra Leone - to work with the aviation and maritime sectors to resolve differences and "develop a coordinated response" to transport issues.

Quarantines may be deemed necessary in areas of intense and widespread transmission of the deadly Ebola virus, the committee statement went on.

"States should ensure that they are proportionate and evidence-based and that accurate information, essential services and commodities, including food and water, are provided to the affected populations."

WHO advisers earlier recommended the screening of travelers departing Ebola-affected countries from airports and ports.

The committee, composed of some 20 experts who advise WHO Director-General Margaret Chan, declared on Aug. 8 that the epidemic constituted a public health emergency of international concern. The medical charity Medecins Sans Frontieres has warned since late March that the outbreak, which began in the remote Gueckedou area of southeastern Guinea, is "unprecedented".

Sierra Leoneans on Sunday celebrated the end of a three-day lockdown meant to stem Ebola's reach, with authorities saying the move had identified dozens of new infections and located scores of bodies.

Separately on Monday, the WHO said two of the five affected countries - Nigeria and Senegal - were managing to halt the spread of the disease.

Tuesday 16 September 2014

Coke, J&J join big corporations behind new employee wellness push

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(Reuters) - Leaders of some of the biggest U.S. corporations, from Coca-Cola Co (KO.N) to Johnson & Johnson (JNJ.N), unveiled a campaign on Tuesday to reduce the nation's healthcare costs, urging their peers to embrace wellness programs to improve employee health.
The newly-formed group, called The CEO Council on Health and Innovation, said it came together "to lead the U.S. business community" in improving employee and community health and reducing costs.
The council's members also include executives from Verizon Communications Inc (VZ.N), Aetna Inc (AET.N), Bank of America Corp (BAC.N), Walgreen Co (WAG.N), McKinsey & Co, Blue Cross and Blue Shield Association and Institute for Advanced Health. Combined, the group said its healthcare benefits cover 150 million people.
In a report released at a press conference in Washington, D.C. in conjunction with the Bipartisan Policy Center, the council called on employers to accelerate the adoption of comprehensive wellness programs that aim to improve nutrition and weight management, promote physical activity, help employees quit smoking and manage chronic diseases.
The group also called on employers to make more use of incentives to increase employee adoption of wellness programs and to modify their health benefits in a way that would encourage workers to take preventive measures to improve health.
Workplace wellness programs, a $6 billion-a-year industry, are a favorite of the business community because they promise to improve productivity, cut absenteeism and reduce medical costs by averting expensive illnesses.
Some employers offer their workers monetary incentives to adhere to the plans, while a smaller group of companies and organizations are introducing penalties for not complying with wellness initiatives.
Several chief executives on the council described their wellness initiatives and cited success in reducing costs for both the employees and the company.
But some research has shown such programs do not always cut costs as hoped.

A long-running workplace wellness program at PepsiCo (PEP.N), for example, helped reduce costs for workers with chronic diseases by cutting down hospital admissions. But the savings for employees who were urged to make preventive changes to their lifestyle were negligible, according to a report published in January.